Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.
Identifieur interne : 000192 ( Main/Exploration ); précédent : 000191; suivant : 000193Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.
Auteurs : Emmanuel Moyse [France] ; Madeleine Arsenault [Canada] ; Pierrette Gaudreau [Canada] ; Guylaine Ferland [Canada] ; Charles Ramassamy [Canada]Source :
- Mechanisms of ageing and development [ 1872-6216 ] ; 2019.
Descripteurs français
- KwdFr :
- Aliment pour animaux (MeSH), Animaux (MeSH), Antioxydants (métabolisme), Cartographie cérébrale (MeSH), Clusterine (métabolisme), Comportement alimentaire (MeSH), Encéphale (métabolisme), Encéphale (physiologie), Glutarédoxines (métabolisme), Glutathion (métabolisme), Hippocampe (anatomopathologie), Longévité (MeSH), Mâle (MeSH), Oxydoréduction (MeSH), Protéine gliofibrillaire acide (métabolisme), Rat Sprague-Dawley (MeSH), Rats (MeSH), Restriction calorique (MeSH), Stress oxydatif (MeSH), Superoxide dismutase-1 (métabolisme), Thiorédoxines (métabolisme), Vieillissement (MeSH).
- MESH :
- anatomopathologie : Hippocampe.
- métabolisme : Antioxydants, Clusterine, Encéphale, Glutarédoxines, Glutathion, Protéine gliofibrillaire acide, Superoxide dismutase-1, Thiorédoxines.
- physiologie : Encéphale.
- Aliment pour animaux, Animaux, Cartographie cérébrale, Comportement alimentaire, Longévité, Mâle, Oxydoréduction, Rat Sprague-Dawley, Rats, Restriction calorique, Stress oxydatif, Vieillissement.
English descriptors
- KwdEn :
- Aging (MeSH), Animal Feed (MeSH), Animals (MeSH), Antioxidants (metabolism), Brain (metabolism), Brain (physiology), Brain Mapping (MeSH), Caloric Restriction (MeSH), Clusterin (metabolism), Feeding Behavior (MeSH), Glial Fibrillary Acidic Protein (metabolism), Glutaredoxins (metabolism), Glutathione (metabolism), Hippocampus (pathology), Longevity (MeSH), Male (MeSH), Oxidation-Reduction (MeSH), Oxidative Stress (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Superoxide Dismutase-1 (metabolism), Thioredoxins (metabolism).
- MESH :
- chemical , metabolism : Antioxidants, Clusterin, Glial Fibrillary Acidic Protein, Glutaredoxins, Glutathione, Superoxide Dismutase-1, Thioredoxins.
- metabolism : Brain.
- pathology : Hippocampus.
- physiology : Brain.
- Aging, Animal Feed, Animals, Brain Mapping, Caloric Restriction, Feeding Behavior, Longevity, Male, Oxidation-Reduction, Oxidative Stress, Rats, Rats, Sprague-Dawley.
Abstract
Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad libitum-fed (AL) rats at 2 and 19 months of age. Four brain structures were compared: hippocampus, striatum, parietal cortex, cerebellum. Our CR diet elicits significant prevention of oxidative damages with the upregulation of antioxidant defenses (levels of glutathione [GSH], mRNAs of clusterin and of three key antioxidant enzymes) as compared to age-matched AL controls, in a strikingly region-specific pattern. CR also prevented a drastic rise of the glial fibrillary acidic protein in the hippocampus of old AL rats. Besides, the CR effects at age 19 months mainly consist in improving endogenous defenses before the onset of age-related redox alterations. These effects are more prominent in the hippocampus.
DOI: 10.1016/j.mad.2019.01.002
PubMed: 30659860
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: Charles.Ramassamy@iaf.inrs.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 4L3</wicri:regionArea><orgName type="university">Université Laval</orgName><placeName><settlement type="city">Québec (ville)</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">Mechanisms of ageing and development</title><idno type="eISSN">1872-6216</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (MeSH)</term><term>Animal Feed (MeSH)</term><term>Animals (MeSH)</term><term>Antioxidants (metabolism)</term><term>Brain (metabolism)</term><term>Brain (physiology)</term><term>Brain Mapping (MeSH)</term><term>Caloric Restriction (MeSH)</term><term>Clusterin (metabolism)</term><term>Feeding Behavior (MeSH)</term><term>Glial Fibrillary Acidic Protein (metabolism)</term><term>Glutaredoxins (metabolism)</term><term>Glutathione (metabolism)</term><term>Hippocampus (pathology)</term><term>Longevity (MeSH)</term><term>Male (MeSH)</term><term>Oxidation-Reduction (MeSH)</term><term>Oxidative Stress (MeSH)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Superoxide Dismutase-1 (metabolism)</term><term>Thioredoxins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aliment pour animaux (MeSH)</term><term>Animaux (MeSH)</term><term>Antioxydants (métabolisme)</term><term>Cartographie cérébrale (MeSH)</term><term>Clusterine (métabolisme)</term><term>Comportement alimentaire (MeSH)</term><term>Encéphale (métabolisme)</term><term>Encéphale (physiologie)</term><term>Glutarédoxines (métabolisme)</term><term>Glutathion (métabolisme)</term><term>Hippocampe (anatomopathologie)</term><term>Longévité (MeSH)</term><term>Mâle (MeSH)</term><term>Oxydoréduction (MeSH)</term><term>Protéine gliofibrillaire acide (métabolisme)</term><term>Rat Sprague-Dawley (MeSH)</term><term>Rats (MeSH)</term><term>Restriction calorique (MeSH)</term><term>Stress oxydatif (MeSH)</term><term>Superoxide dismutase-1 (métabolisme)</term><term>Thiorédoxines (métabolisme)</term><term>Vieillissement (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Clusterin</term><term>Glial Fibrillary Acidic Protein</term><term>Glutaredoxins</term><term>Glutathione</term><term>Superoxide Dismutase-1</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hippocampe</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term><term>Clusterine</term><term>Encéphale</term><term>Glutarédoxines</term><term>Glutathion</term><term>Protéine gliofibrillaire acide</term><term>Superoxide dismutase-1</term><term>Thiorédoxines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aging</term><term>Animal Feed</term><term>Animals</term><term>Brain Mapping</term><term>Caloric Restriction</term><term>Feeding Behavior</term><term>Longevity</term><term>Male</term><term>Oxidation-Reduction</term><term>Oxidative Stress</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aliment pour animaux</term><term>Animaux</term><term>Cartographie cérébrale</term><term>Comportement alimentaire</term><term>Longévité</term><term>Mâle</term><term>Oxydoréduction</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Restriction calorique</term><term>Stress oxydatif</term><term>Vieillissement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad libitum-fed (AL) rats at 2 and 19 months of age. Four brain structures were compared: hippocampus, striatum, parietal cortex, cerebellum. Our CR diet elicits significant prevention of oxidative damages with the upregulation of antioxidant defenses (levels of glutathione [GSH], mRNAs of clusterin and of three key antioxidant enzymes) as compared to age-matched AL controls, in a strikingly region-specific pattern. CR also prevented a drastic rise of the glial fibrillary acidic protein in the hippocampus of old AL rats. Besides, the CR effects at age 19 months mainly consist in improving endogenous defenses before the onset of age-related redox alterations. These effects are more prominent in the hippocampus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30659860</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-6216</ISSN><JournalIssue CitedMedium="Internet"><Volume>179</Volume><PubDate><Year>2019</Year><Month>04</Month></PubDate></JournalIssue><Title>Mechanisms of ageing and development</Title><ISOAbbreviation>Mech Ageing Dev</ISOAbbreviation></Journal><ArticleTitle>Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.</ArticleTitle><Pagination><MedlinePgn>51-59</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0047-6374(18)30176-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.mad.2019.01.002</ELocationID><Abstract><AbstractText>Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad libitum-fed (AL) rats at 2 and 19 months of age. Four brain structures were compared: hippocampus, striatum, parietal cortex, cerebellum. Our CR diet elicits significant prevention of oxidative damages with the upregulation of antioxidant defenses (levels of glutathione [GSH], mRNAs of clusterin and of three key antioxidant enzymes) as compared to age-matched AL controls, in a strikingly region-specific pattern. CR also prevented a drastic rise of the glial fibrillary acidic protein in the hippocampus of old AL rats. Besides, the CR effects at age 19 months mainly consist in improving endogenous defenses before the onset of age-related redox alterations. These effects are more prominent in the hippocampus.</AbstractText><CopyrightInformation>Copyright © 2019. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moyse</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Laboratory of Neuroendocrinology of Aging, Centre Hospitalier de l'Université de Montréal, 900 St-Denis Street, R Pavilion, Rm R05.436B-02, Montreal, QC, H2X0A9, Canada; Physiology of Reproduction and Behaviour Unit (PRC), University of Tours, INRA Centre of Tours, F-37380, Nouzilly, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arsenault</LastName><ForeName>Madeleine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaudreau</LastName><ForeName>Pierrette</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Neuroendocrinology of Aging, Centre Hospitalier de l'Université de Montréal, 900 St-Denis Street, R Pavilion, Rm R05.436B-02, Montreal, QC, H2X0A9, Canada; Department of Medicine, University of Montreal, Montreal, QC, H3C 3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferland</LastName><ForeName>Guylaine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institut de cardiologie de Montréal Research Center, Montreal, QC, H4J 1C5, Canada; Department of Nutrition, University of Montreal, Montreal, QC, H1T 1C8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramassamy</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 4L3, Canada. Electronic address: Charles.Ramassamy@iaf.inrs.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>CIHR</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Mech Ageing Dev</MedlineTA><NlmUniqueID>0347227</NlmUniqueID><ISSNLinking>0047-6374</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C498500">Clu protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051152">Clusterin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000614142">GFAP protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005904">Glial Fibrillary Acidic Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>52500-60-4</RegistryNumber><NameOfSubstance UI="D013879">Thioredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="C000606292">Sod1 protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D000072105">Superoxide Dismutase-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>GAN16C9B8O</RegistryNumber><NameOfSubstance UI="D005978">Glutathione</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="Y">Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000821" MajorTopicYN="N">Animal Feed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001931" MajorTopicYN="N">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031204" MajorTopicYN="Y">Caloric Restriction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051152" MajorTopicYN="N">Clusterin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005247" MajorTopicYN="N">Feeding Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005904" MajorTopicYN="N">Glial Fibrillary Acidic Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005978" MajorTopicYN="N">Glutathione</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008136" MajorTopicYN="N">Longevity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="Y">Oxidation-Reduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072105" MajorTopicYN="N">Superoxide Dismutase-1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013879" MajorTopicYN="N">Thioredoxins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Clusterin</Keyword><Keyword MajorTopicYN="Y">Glial fibrillary acidic protein</Keyword><Keyword MajorTopicYN="Y">Glutaredoxine-1</Keyword><Keyword MajorTopicYN="Y">Glutathione</Keyword><Keyword MajorTopicYN="Y">Superoxide dismutase-1</Keyword><Keyword MajorTopicYN="Y">Thioredoxine-1</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30659860</ArticleId><ArticleId IdType="pii">S0047-6374(18)30176-3</ArticleId><ArticleId IdType="doi">10.1016/j.mad.2019.01.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Centre-Val de Loire</li><li>Québec</li><li>Région Centre</li></region><settlement><li>Nouzilly</li><li>Québec (ville)</li></settlement><orgName><li>Université Laval</li></orgName></list><tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Moyse, Emmanuel" sort="Moyse, Emmanuel" uniqKey="Moyse E" first="Emmanuel" last="Moyse">Emmanuel Moyse</name></region></country><country name="Canada"><noRegion><name sortKey="Arsenault, Madeleine" sort="Arsenault, Madeleine" uniqKey="Arsenault M" first="Madeleine" last="Arsenault">Madeleine Arsenault</name></noRegion><name sortKey="Ferland, Guylaine" sort="Ferland, Guylaine" uniqKey="Ferland G" first="Guylaine" last="Ferland">Guylaine Ferland</name><name sortKey="Gaudreau, Pierrette" sort="Gaudreau, Pierrette" uniqKey="Gaudreau P" first="Pierrette" last="Gaudreau">Pierrette Gaudreau</name><name sortKey="Ramassamy, Charles" sort="Ramassamy, Charles" uniqKey="Ramassamy C" first="Charles" last="Ramassamy">Charles Ramassamy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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